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恶性吞咽困难的姑息性激光治疗

Palliative laser therapy for malignant dysphagia.

作者信息

Krasner N, Barr H, Skidmore C, Morris A I

机构信息

Gastrointestinal Unit, Walton Hospital, Liverpool.

出版信息

Gut. 1987 Jul;28(7):792-8. doi: 10.1136/gut.28.7.792.

Abstract

Seventy six patients with dysphagia caused by malignant tumours of the oesophagus or gastric cardia have been treated using the Neodymium Yttrium Aluminium Garnet (NdYag) laser. The laser was set to deliver 80-100 watts of power for 0.5-1 second pulses. To obtain improvement, patients on average needed four treatment sessions with a mean energy per treatment of 3586 joules. Follow up endoscopy and laser treatment was at four week intervals, unless the clinical or endoscopic results indicated otherwise. The immediate result was to allow 32% of patients to swallow anything they liked, a further 54% were able to take most solids and 9% were improved, or maintained on liquids only. The mortality of laser recanalisation and associated treatment was 5%. The improvement in swallowing was maintained until death in all but 15% of these patients, some of the 15% needed intubation to allow adequate swallowing. Endoscopic, or surgical intubation was required immediately in five patients after an initial laser course failed to provide improvement. The mean survival of the whole group was 19 weeks (range one to 112 weeks).

摘要

76例因食管或贲门恶性肿瘤导致吞咽困难的患者接受了钕钇铝石榴石(NdYag)激光治疗。激光设置为以80 - 100瓦的功率输出0.5 - 1秒的脉冲。为取得疗效,患者平均需要接受4次治疗,每次治疗的平均能量为3586焦耳。除非临床或内镜检查结果另有指示,随访内镜检查和激光治疗每隔4周进行一次。即刻结果是,32%的患者能够吞咽任何他们想吃的东西,另有54%的患者能够进食大多数固体食物,9%的患者病情有所改善,或仅能维持流质饮食。激光再通及相关治疗的死亡率为5%。除15%的患者外,其余患者吞咽功能的改善一直维持到死亡,这15%的患者中有部分需要插管以实现充分吞咽。在初始激光治疗未能改善病情后,有5名患者立即需要进行内镜或手术插管。整个组的平均生存期为19周(范围为1至112周)。

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