Department of Dermatology, Chaim Sheba Medical Center, Tel-Aviv University, Sackler School of Medicine, Tel Hashomer, Israel.
Department of Dermatology, Chaim Sheba Medical Center, Tel-Aviv University, Sackler School of Medicine, Tel Hashomer, Israel.
Autoimmun Rev. 2014 Apr-May;13(4-5):482-9. doi: 10.1016/j.autrev.2014.01.047. Epub 2014 Jan 13.
Blistering skin diseases are a group of autoimmune disorders that are characterized by autoantibodies against structural proteins of the epidermis or the dermal-epidermal junction and clinically by blisters and erosions on skin and/or mucous membranes. Since clinical criteria and histopathological characteristics are not sufficient for diagnosis, direct immunofluorescence microscopy of a biopsy specimen or serological tests are needed for exact diagnosis. The differentiation between the various disorders became more important since prognosis as well as different treatment options are nowadays available for the various diseases. Moreover, some bullous diseases may indicate the presence of an underlying malignancy. The detection of serum autoantibodies have been shown to correlate with disease activity and thus may be helpful in deciding treatment options for these patients.
水疱性皮肤病是一组自身免疫性疾病，其特征是针对表皮或表皮-真皮交界处的结构蛋白的自身抗体，临床上表现为皮肤和/或粘膜上的水疱和糜烂。由于临床标准和组织病理学特征不足以用于诊断，因此需要对活检标本进行直接免疫荧光显微镜检查或血清学检查以进行准确诊断。由于目前各种疾病都有不同的预后和治疗选择，因此区分各种疾病变得更加重要。此外，一些大疱性疾病可能表明存在潜在的恶性肿瘤。已发现血清自身抗体的检测与疾病活动相关，因此可能有助于为这些患者选择治疗方案。
