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不同锶制剂（雷奈酸锶、柠檬酸盐和氯化物）对去卵巢骨质疏松症雌性小鼠模型骨密度、形态和微结构的影响：一项比较研究。

Influence of Various Strontium Formulations (Ranelate, Citrate, and Chloride) on Bone Mineral Density, Morphology, and Microarchitecture: A Comparative Study in an Ovariectomized Female Mouse Model of Osteoporosis.

机构信息

Laboratory of Locomotor Systems Research, Department of Rehabilitation and Physiotherapy, Medical University of Lublin, 20-954 Lublin, Poland.

Department of Orthopaedics and Rehabilitation, Medical University of Lublin, 20-954 Lublin, Poland.

出版信息

Int J Mol Sci. 2024 Apr 6;25(7):4075. doi: 10.3390/ijms25074075.

DOI:10.3390/ijms25074075
PMID:38612883
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11012416/
Abstract

Osteoporosis stands out as a prevalent skeletal ailment, prompting exploration into potential treatments, including dietary strontium ion supplements. This study assessed the efficacy of supplementation of three strontium forms-strontium citrate (SrC), strontium ranelate (SrR), and strontium chloride (SrCl)-for enhancing bone structure in 50 female SWISS mice, aged seven weeks. In total, 40 mice underwent ovariectomy, while 10 underwent sham ovariectomy. Ovariectomized (OVX) mice were randomly assigned to the following groups: OVX (no supplementation), OVX + SrR, OVX + SrC, and OVX + SrCl, at concentrations equivalent to the molar amount of strontium. After 16 weeks, micro-CT examined trabeculae and cortical bones, and whole-bone strontium content was determined. Results confirm strontium administration increased bone tissue mineral density (TMD) and Sr content, with SrC exhibiting the weakest effect. Femur morphometry showed limited Sr impact, especially in the OVX + SrC group. This research highlights strontium's potential in bone health, emphasizing variations in efficacy among its forms.

摘要

骨质疏松症是一种常见的骨骼疾病，促使人们探索潜在的治疗方法，包括饮食中补充锶离子。本研究评估了三种锶形式（柠檬酸锶（SrC）、雷奈酸锶（SrR）和氯化锶（SrCl））补充剂对增强 50 只 7 周龄瑞士雌性小鼠骨结构的功效。共有 40 只小鼠接受了卵巢切除术，而 10 只接受了假手术。去卵巢（OVX）小鼠被随机分配到以下组：OVX（无补充）、OVX+SrR、OVX+SrC 和 OVX+SrCl，锶浓度与摩尔量相当。16 周后，使用 micro-CT 检查小梁骨和皮质骨，并测定全骨锶含量。结果证实锶的给药增加了骨组织矿物质密度（TMD）和 Sr 含量，其中 SrC 的效果最弱。股骨形态计量学显示 Sr 的影响有限，尤其是在 OVX+SrC 组。本研究强调了锶在骨骼健康中的潜在作用，同时也强调了其形式之间的功效差异。

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