Kyriakou A, Patsatsi A, Patsialas C, Sotiriadis D
2nd Dermatology Department, Aristotle University School of Medicine, Thessaloniki, Greece.
Dermatology. 2014;228(1):18-23. doi: 10.1159/000357153. Epub 2014 Jan 9.
Plasma cell balanitis of Zoon (PCBZ) and plasma cell vulvitis (PCV) are characterized as idiopathic, benign, chronic irritant mucositis. The clinical symptoms and signs usually persist or reappear after treatment withdrawal. Therefore, many therapies have been tried and are available. Recently, several reports of PCBZ and PCV treated with calcineurin inhibitors, tacrolimus and pimecrolimus, have been reported in the literature. We present 9 cases of PCBZ treated with tacrolimus 0.1% ointment (Protopic, Toyama, Japan) that showed good therapeutic results within 4 weeks of treatment, and we review the literature of PCBZ and PCV and their response to these topical immunomodulators. Based on the current literature and on the anecdotal experience, we believe that topical calcineurin inhibitors may serve as a therapeutic option in recalcitrant plasma cell balanitis and vulvitis.
佐恩浆细胞性龟头炎（PCBZ）和浆细胞性外阴炎（PCV）的特征为特发性、良性、慢性刺激性黏膜炎症。临床症状和体征在治疗停药后通常会持续或复发。因此，人们尝试了多种治疗方法且都有应用。最近，文献中报道了几例用钙调神经磷酸酶抑制剂他克莫司和吡美莫司治疗PCBZ和PCV的病例。我们报告了9例用0.1%他克莫司软膏（普特彼，日本富山）治疗的PCBZ病例，这些病例在治疗4周内显示出良好的治疗效果，并且我们回顾了PCBZ和PCV的文献以及它们对这些局部免疫调节剂的反应。基于当前的文献和经验，我们认为局部钙调神经磷酸酶抑制剂可能是治疗顽固性浆细胞性龟头炎和外阴炎的一种治疗选择。
