Centro Studi GISED, Fondazione per la Ricerca Ospedale Maggiore, Bergamo, Italy.
Dermatology. 2014;228(2):166-71. doi: 10.1159/000357221. Epub 2014 Jan 9.
BACKGROUND/AIMS: Rubbing the skin may influence the persistence of pustulosis over time. The aim of this study was to assess the impact of a new fabric made with fluorine-synthetic fiber in improving plantar pustulosis.
A total of 17 patients were randomized to receive on one side a sock made of fluorine-synthetic fiber and on the other a sock made of cotton fabric for 4 weeks. The main outcome was the percentage reduction of lesional area at week 4.
The median lesion reduction at week 4 was 42.6% in the fluorine-synthetic fiber arm and 2.7% in the cotton arm (p = 0.148). Among secondary outcomes, the overall reduction over time in the treated areas was significantly in favor of the fluorine-synthetic fiber arm (p = 0.045) as well as the perception of the disease by the patient (p = 0.025).
Despite the fact that the primary outcome was not reached, there was a tangible reduction in the extension of the treated areas and in the perception of the disease by the patient.
背景/目的：摩擦皮肤可能会影响脓疱病的持续时间。本研究旨在评估一种新型氟合成纤维织物对改善足底脓疱病的影响。
共有 17 名患者随机分配到一侧穿氟合成纤维制成的袜子，另一侧穿棉织物制成的袜子，持续 4 周。主要结局是第 4 周时病变面积的百分比减少。
氟合成纤维组第 4 周时病变减少中位数为 42.6%，棉组为 2.7%（p = 0.148）。在次要结局中，治疗区域的总体随时间减少明显更有利于氟合成纤维组（p = 0.045）以及患者对疾病的感知（p = 0.025）。
尽管主要结局未达到，但治疗区域的扩展和患者对疾病的感知都有明显减少。
