Patel Sita Sharan, Udayabanu Malairaman
Jaypee University of Information Technology, Waknaghat, Himachal Pradesh, 173234, India.
Metab Brain Dis. 2014 Mar;29(1):121-30. doi: 10.1007/s11011-014-9480-0. Epub 2014 Jan 17.
Evidences suggest that glucocorticoids results in depression and is a risk factor for type 2 diabetes. Further diabetes induces oxidative stress and hippocampal dysfunction resulting in cognitive decline. Traditionally Urtica dioica has been used for diabetes mellitus and cognitive dysfunction. The present study investigated the effect of the hydroalcoholic extract of Urtica dioica leaves (50 and 100 mg/kg, p.o.) in dexamethasone (1 mg/kg, i.m.) induced diabetes and its associated complications such as depressive like behavior and cognitive dysfunction. We observed that mice administered with chronic dexamethasone resulted in hypercortisolemia, oxidative stress, depressive like behavior, cognitive impairment, hyperglycemia with reduced body weight, increased water intake and decreased hippocampal glucose transporter-4 (GLUT4) mRNA expression. Urtica dioica significantly reduced hyperglycemia, plasma corticosterone, oxidative stress and depressive like behavior as well as improved associative memory and hippocampal GLUT4 mRNA expression comparable to rosiglitazone (5 mg/kg, p.o.). Further, Urtica dioica insignificantly improved spatial memory and serum insulin. In conclusion, Urtica dioica reversed dexamethasone induced hyperglycemia and its associated complications such as depressive like behavior and cognitive dysfunction.
有证据表明，糖皮质激素会导致抑郁，且是2型糖尿病的一个风险因素。此外，糖尿病会引发氧化应激和海马体功能障碍，从而导致认知能力下降。传统上，荨麻已被用于治疗糖尿病和认知功能障碍。本研究调查了荨麻叶水醇提取物（50和100毫克/千克，口服）对地塞米松（1毫克/千克，肌肉注射）诱导的糖尿病及其相关并发症（如抑郁样行为和认知功能障碍）的影响。我们观察到，长期给予地塞米松的小鼠会出现高皮质醇血症、氧化应激、抑郁样行为、认知障碍、高血糖伴体重减轻、饮水量增加以及海马体葡萄糖转运蛋白4（GLUT4）mRNA表达降低。荨麻能显著降低高血糖、血浆皮质酮、氧化应激和抑郁样行为，还能改善联想记忆和海马体GLUT4 mRNA表达，效果与罗格列酮（5毫克/千克，口服）相当。此外，荨麻对空间记忆和血清胰岛素有轻微改善作用。总之，荨麻可逆转地塞米松诱导的高血糖及其相关并发症，如抑郁样行为和认知功能障碍。
