Programa de Pós-Graduação em Medicina e Ciências da Saúde, Escola de Medicina, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS 90619-900, Brazil.
Centro de Pesquisas em Toxicologia e Farmacologia, Escola de Ciências da Saúde e da Vida, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS 90619-900, Brazil.
Nutrients. 2021 Apr 2;13(4):1177. doi: 10.3390/nu13041177.
Dry extracts from the Eurasian plants, , , and have been used as anabolic supplements, despite the limited scientific data on these effects. To assess their actions on early sarcopenia signs, male and female castrated mice were supplemented with lyophilized extracts of the three plants, isolated or in association (named TLU), and submitted to resistance exercise. Ovariectomy (OVX) led to body weight increase and non-high-density cholesterol (HDL) cholesterol elevation, which had been restored by exercise plus extract, or by exercise and TLU, respectively. Orchiectomy (ORX) caused skeletal muscle weight loss, accompanied by increased adiposity, being the latter parameter reduced by exercise plus or extracts. General physical activity was improved by exercise plus herbal extracts in either OVX or ORX animals. Exercise combined with TLU improved resistance to fatigue in OVX animals, though enhanced the grip strength in ORX mice. or TLU also reduced the ladder climbing time in ORX mice. Resistance exercise plus herbal extracts partly altered gastrocnemius fiber size frequencies in OVX or ORX mice. We provide novel data that tested ergogenic extracts, when combined with resistance exercise, improved early sarcopenia alterations in castrated male and female mice.
欧亚植物的干提取物、、、已被用作合成代谢补充剂，尽管这些作用的科学数据有限。为了评估它们对早期骨骼肌减少症迹象的作用，雄性和雌性去势小鼠用三种植物的冻干提取物（单独或联合，命名为 TLU）进行补充，并接受抗阻运动。卵巢切除术（OVX）导致体重增加和非高密度胆固醇（HDL）胆固醇升高，这些变化分别通过运动加提取物或运动和 TLU 得以恢复。去势（ORX）导致骨骼肌重量减轻，同时脂肪增多，后者参数通过运动加或提取物减少。在 OVX 或 ORX 动物中，一般身体活动通过运动加草药提取物得到改善。运动加 TLU 改善了 OVX 动物的抗疲劳能力，而提取物增强了 ORX 小鼠的握力。或 TLU 也减少了 ORX 小鼠的爬梯时间。抗阻运动加草药提取物部分改变了 OVX 或 ORX 小鼠的比目鱼肌纤维大小频率。我们提供了新的数据，这些数据测试了运动补充剂，当与抗阻运动结合使用时，可以改善去势雄性和雌性小鼠的早期骨骼肌减少症变化。
