Nolan Heather R, Davenport Daniel L, Ramaiah Chandrashekhar
Department of Surgery, Mercer University School of Medicine, Macon, Georgia.
Department of Surgery, University of Kentucky College of Medicine, Lexington, Kentucky.
Int J Angiol. 2013 Mar;22(1):31-6. doi: 10.1055/s-0033-1333865.
Background An increasing obese population in the United States focuses attention on perioperative management of obese and overweight patients. Objective We sought to determine if obesity, determined by body mass index (BMI), was a preoperative indicator of bleeding in coronary artery bypass graft (CABG) surgery as measured by intraoperative packed red blood cell transfusion frequency and 24-hour chest-tube output amount. Methods A retrospective chart review examined 290 consecutive patients undergoing single-surgeon off-pump or on-pump CABG surgery between November 2003 and April 2009. Preoperative variables of age, gender, hematocrit, platelet count, and BMI, chest tube output during the immediate 24-hour postoperative period, and the type of procedure (on-pump vs. off-pump) were analyzed. Logistic regression analysis was used to evaluate the likelihood of intraoperative transfusion. Linear regression analysis was used to evaluate 24-hour chest-tube output. Results Preoperative variables that significantly increased the likelihood of intraoperative transfusions were older age and low hematocrit; a significant decrease in likelihood was found with male gender, overweight BMI, and off-pump procedures. Preoperative variables that significantly increased 24-hour chest-tube output were low hematocrit, high hematocrit, and low platelets while a significant decrease in output was seen with overweight BMI and obese BMI. Conclusion Overweight and obese BMI are significant independent predictors of decreased intraoperative transfusion and decreased postoperative blood loss.
美国肥胖人群日益增多,这使得肥胖和超重患者的围手术期管理备受关注。
我们试图确定,通过体重指数(BMI)判定的肥胖是否是冠状动脉搭桥术(CABG)手术中出血的术前指标,衡量指标为术中浓缩红细胞输注频率和术后24小时胸腔引流管引流量。
一项回顾性图表审查研究了2003年11月至2009年4月期间连续接受单名外科医生非体外循环或体外循环CABG手术的290例患者。分析术前变量,包括年龄、性别、血细胞比容、血小板计数和BMI、术后24小时内的胸腔引流管引流量以及手术类型(体外循环与非体外循环)。采用逻辑回归分析评估术中输血的可能性。采用线性回归分析评估术后24小时胸腔引流管引流量。
显著增加术中输血可能性的术前变量为年龄较大和血细胞比容较低;而男性、超重BMI和非体外循环手术则显著降低输血可能性。显著增加术后24小时胸腔引流管引流量的术前变量为血细胞比容较低、血细胞比容较高和血小板计数较低,而超重BMI和肥胖BMI则显著减少引流量。
超重和肥胖BMI是术中输血减少和术后失血减少的重要独立预测因素。