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西班牙裔患者群体中左心室舒张功能障碍的患病率及预测因素

Prevalence and predictors of left ventricular diastolic dysfunction in a Hispanic patient population.

作者信息

Castro Carlos E Rodríguez, Lyapin Alexander, Pattathan Mithun, Negrin José, Mukherjee Debabrata

机构信息

Department of Internal Medicine, Texas Tech University Health Science Center, El Paso, Texas.

出版信息

Int J Angiol. 2013 Dec;22(4):229-34. doi: 10.1055/s-0033-1353240.

Abstract

Minimal data exist on attributes of diastolic dysfunction in the Hispanic population. The purpose of this study was to evaluate the prevalence and predictors of diastolic dysfunction in a Hispanic patient population. We performed a retrospective review of 166 consecutive echocardiograms in a southwestern Texas Hospital that caters to a large Hispanic patient population. We identified all echocardiograms that met criteria for diastolic dysfunction and assessed baseline demographics and comorbidities in the cohort of Hispanic patients. A multivariate analysis was performed to identify the independent predictors of diastolic dysfunction. A total of 129 out of 166 patients (77.8%) were of Hispanic origin. Out of the 129 patients, 87 (67.4%) had some degree of diastolic dysfunction in this population suggesting a high prevalence in the study cohort. In the diastolic dysfunction group, the mean age was 64.5 ± 13.9, 37% were male and 63% female, 78% had diabetes, 85% had hypertension, and 49% had some degree of renal insufficiency (stages 3-5). A logistic multivariate analysis showed that diabetes was an independent predictor of diastolic dysfunction with odds ratio of 2.69 (95% confidence interval [CI], 1.06-6.28; p = 0.038). Similarly age (per year increase) and chronic kidney disease were independent predictors of diastolic dysfunction. We demonstrated that older age, presence of diabetes, and renal dysfunction are independent predictors of diastolic dysfunction in the Hispanic patient population. Strategies geared toward reducing diabetes and preventing renal dysfunction are likely to decrease prevalence of diastolic dysfunction and heart failure in this community.

摘要

关于西班牙裔人群舒张功能障碍特征的数据极少。本研究的目的是评估西班牙裔患者人群中舒张功能障碍的患病率及预测因素。我们对德克萨斯州西南部一家服务于大量西班牙裔患者的医院连续166份超声心动图进行了回顾性分析。我们确定了所有符合舒张功能障碍标准的超声心动图,并评估了西班牙裔患者队列的基线人口统计学特征和合并症。进行多变量分析以确定舒张功能障碍的独立预测因素。166名患者中共有129名(77.8%)为西班牙裔。在这129名患者中,87名(67.4%)在该人群中存在某种程度的舒张功能障碍,表明该研究队列中的患病率较高。在舒张功能障碍组中,平均年龄为64.5±13.9岁,男性占37%,女性占63%,78%患有糖尿病,85%患有高血压,49%有某种程度的肾功能不全(3 - 5期)。多变量逻辑分析显示,糖尿病是舒张功能障碍的独立预测因素,比值比为2.69(95%置信区间[CI],1.06 - 6.28;p = 0.038)。同样,年龄(每年增加)和慢性肾脏病是舒张功能障碍的独立预测因素。我们证明,高龄、糖尿病的存在和肾功能不全是西班牙裔患者人群舒张功能障碍的独立预测因素。旨在减少糖尿病和预防肾功能不全的策略可能会降低该社区舒张功能障碍和心力衰竭的患病率。

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