Kaczmarek Katarzyna, Morales Ayana, Henderson Andrew J
Graduate Program in Molecular and Translational Medicine, Boston University School of Medicine, Boston, MA.
Section of Infectious Diseases and Department of Medicine, Boston University School of Medicine, Boston, MA.
Virology (Auckl). 2013 Sep 24;2013(4):41-47. doi: 10.4137/VRT.S12147.
By targeting CD4 effector T cells, HIV has a dramatic impact on the depletion, expansion and function of the different polarized T cell subsets. The maturation of T cell lineages is in part driven by intrinsic transcription factors that potentially influence how efficiently HIV replicates. In this review, we explore whether transcription factors that are required for polarizing T cells influence HIV replication. In particular, we examine provirus transcription as well as the establishment and maintenance of HIV latency. Furthermore, it is suggested these factors may provide novel cell-specific therapeutic strategies for targeting the HIV latent reservoir.
通过靶向CD4效应T细胞，HIV对不同极化T细胞亚群的耗竭、扩增和功能产生了巨大影响。T细胞谱系的成熟部分由内在转录因子驱动，这些转录因子可能影响HIV复制的效率。在本综述中，我们探讨极化T细胞所需的转录因子是否会影响HIV复制。特别是，我们研究了前病毒转录以及HIV潜伏的建立和维持。此外，有人认为这些因素可能为靶向HIV潜伏库提供新的细胞特异性治疗策略。
