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后路脊柱内固定置入术后硬纤维瘤形成

Desmoid Tumor Formation following Posterior Spinal Instrumentation Placement.

作者信息

Puvanesarajah Varun, Lina Ioan A, Liauw Jason A, Hsu Wesley, Burger Peter C, Witham Timothy F

机构信息

Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States.

Department of Neurosurgery, Wake Forest University Baptist Medical Center, Baltimore, Maryland, United States.

出版信息

Evid Based Spine Care J. 2013 Oct;4(2):137-42. doi: 10.1055/s-0033-1357356.

Abstract

Study Design Case report. Objective The objective of the article is to illustrate a case of desmoid tumor (DT) formation after posterior instrumentation of the thoracic spine. Methods A 57-year-old woman presented with lower extremity clumsiness, balance, and ambulation difficulty resulting from spinal cord compression due to an upper thoracic atypical vertebral hemangioma. Ten months after undergoing embolization, resection, and placement of instrumentation for this lesion, the patient developed a growing mass at the rostral end of the incision. Biopsy revealed desmoid fibromatosis. The mass was removed via an en bloc resection. Histology revealed an infiltrative DT above the laminectomy site abutting the instrumentation. Results At 2-year follow-up, there was no evidence of recurrence of the tumor. Conclusion Paraspinal DTs have been reported in the literature to develop after surgical procedures of the spine. Often times, patients attribute swelling or fullness at the site of their surgery to scar tissue formation or instrumentation. One must consider the possibility of a DT in the setting of reported surgical site fullness or mass after spine surgery. It is thought that postoperative inflammation present in the surgical bed may promote formation of DTs. Instrumentation may also contribute to inflammation and increase the likelihood of developing a DT. Generous margins must be taken to prevent recurrence.

摘要

研究设计 病例报告。目的 本文旨在阐述一例胸椎后路内固定术后发生硬纤维瘤(DT)的病例。方法 一名57岁女性因上胸椎非典型椎体血管瘤导致脊髓受压,出现下肢笨拙、平衡及行走困难。针对该病变进行栓塞、切除及内固定术后10个月,患者切口头端出现一个不断增大的肿块。活检显示为硬纤维瘤病。通过整块切除将肿块切除。组织学检查显示在椎板切除部位上方有一个浸润性DT,紧邻内固定装置。结果 在2年的随访中,没有肿瘤复发的证据。结论 文献报道脊柱手术后会发生椎旁DT。通常情况下,患者将手术部位的肿胀或饱满归因于瘢痕组织形成或内固定装置。在脊柱手术后报告手术部位饱满或有肿块的情况下,必须考虑DT的可能性。据认为,手术床中存在的术后炎症可能促进DT的形成。内固定装置也可能导致炎症并增加发生DT的可能性。必须切除足够的边缘组织以防止复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8514/3836896/3be1f2962670/10-1055-s-0033-1357356-i1300006cr-1.jpg

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