Nakao Atsuhito
Department of Immunology, Faculty of Medicine, University of Yamanashi.
Nihon Rinsho. 2013 Dec;71(12):2153-7.
IgE-mediated immediate-type allergic reactions in the skin show a diurnal rhythm, although the regulatory mechanisms are poorly understood. In mammals, the circadian rhythms are driven by the circadian clock system consisting of the light-entrained central clock located in the suprachiasmatic nucleus(SCN) of the hypothalamus and peripheral oscillators present in nearly all cell types. We have recently shown that the circadian clocks drive the daily rhythms of IgE-mediated allergic reactions in the skin by using a passive cutaneous anaphylactic reaction model in mice. We also found that systemic anaphylactic reaction shows a time of day-dependent variation, which relied on the circadian clocks. These findings highlight the circadian clocks as an important regulatory component of local and systemic allergic reaction.
皮肤中IgE介导的速发型过敏反应呈现昼夜节律，尽管其调节机制尚不清楚。在哺乳动物中，昼夜节律由昼夜节律时钟系统驱动，该系统由位于下丘脑视交叉上核（SCN）的光驱动中央时钟和几乎所有细胞类型中存在的外周振荡器组成。我们最近发现，昼夜节律时钟通过在小鼠中使用被动皮肤过敏反应模型来驱动皮肤中IgE介导的过敏反应的每日节律。我们还发现，全身过敏反应呈现出依赖于昼夜节律时钟的一天中不同时间的变化。这些发现突出了昼夜节律时钟作为局部和全身过敏反应的重要调节成分。
