• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

通过 Ag(I)-催化的亲核试剂对 9-烯丙基-9H-嘌呤的加成反应构建无环核苷的新策略。

A new strategy to construct acyclic nucleosides via Ag(I)-catalyzed addition of pronucleophiles to 9-allenyl-9H-purines.

机构信息

Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University , Xinxiang, Henan 453007, P. R. China.

出版信息

Org Lett. 2014 Feb 7;16(3):900-3. doi: 10.1021/ol4036566. Epub 2014 Jan 17.

DOI:10.1021/ol4036566
PMID:24437554
Abstract

A new strategy to construct acyclic nucleosides with diverse side chains was developed. With Ag(I) salts as catalysts, the hydrocarboxylation, hydroamination, and hydrocarbonation reactions proceeded well, affording acyclic nucleosides in good yields (41 examples, 60-98% yields). Meanwhile, these reactions exhibited high chemoselectivities and E-selectivities.

摘要

开发了一种构建具有不同侧链的无环核苷的新策略。在 Ag(I)盐作为催化剂的条件下，氢羧化、氢氨化和氢化反应顺利进行，以良好的收率（41 个实例，60-98%的收率）得到了无环核苷。同时，这些反应表现出高化学选择性和 E-选择性。

相似文献

1
A new strategy to construct acyclic nucleosides via Ag(I)-catalyzed addition of pronucleophiles to 9-allenyl-9H-purines.通过 Ag(I)-催化的亲核试剂对 9-烯丙基-9H-嘌呤的加成反应构建无环核苷的新策略。
Org Lett. 2014 Feb 7;16(3):900-3. doi: 10.1021/ol4036566. Epub 2014 Jan 17.
2
Diversity-oriented synthesis of acyclic nucleosides via ring-opening of vinyl cyclopropanes with purines.通过乙烯基环丙烷与嘌呤的开环反应实现无环核苷的多样性导向合成。
Chem Commun (Camb). 2015 Feb 25;51(16):3328-31. doi: 10.1039/c4cc09844g.
3
Synthesis of Azacyclic Nucleoside Analogues via Asymmetric [3 + 2] Cycloaddition of 9-(2-Tosylvinyl)-9H-purines.通过9-(2-甲苯磺酰基乙烯基)-9H-嘌呤的不对称[3+2]环加成反应合成氮杂环核苷类似物
Org Lett. 2016 Feb 19;18(4):820-3. doi: 10.1021/acs.orglett.6b00108. Epub 2016 Feb 4.
4
Pd-catalyzed amination of nucleoside arylsulfonates to yield N6-aryl-2,6-diaminopurine nucleosides.钯催化核苷芳基磺酸盐胺化反应以生成N6-芳基-2,6-二氨基嘌呤核苷。
Angew Chem Int Ed Engl. 2004 Nov 26;43(46):6372-7. doi: 10.1002/anie.200460782.
5
An efficient approach to the synthesis of nucleosides: gold(I)-catalyzed N-glycosylation of pyrimidines and purines with glycosyl ortho-alkynyl benzoates.一种核苷合成的有效方法：金（I）催化嘧啶和嘌呤与邻炔基苯甲酸糖酯的N-糖基化反应。
Angew Chem Int Ed Engl. 2011 May 16;50(21):4933-6. doi: 10.1002/anie.201100514. Epub 2011 Apr 15.
6
One-pot TiO2-catalyzed synthesis of nucleic bases and acyclonucleosides from formamide: implications for the origin of life.一锅法TiO₂催化由甲酰胺合成核酸碱基和无环核苷：对生命起源的启示
Chembiochem. 2003 Jun 6;4(6):514-21. doi: 10.1002/cbic.200300567.
7
7-substituted 8-aza-7-deazapurines and 2,8-diaza-7-deaza-purines: synthesis of nucleosides and oligonucleotides.7-取代的8-氮杂-7-脱氮嘌呤和2,8-二氮杂-7-脱氮嘌呤：核苷和寡核苷酸的合成
Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):869-73. doi: 10.1081/ncn-200059218.
8
Microwave-assisted amination of a chloropurine derivative in the synthesis of acyclic nucleoside analogues.无环核苷类似物合成中氯嘌呤衍生物的微波辅助胺化反应。
Molecules. 2005 Feb 28;10(2):508-15. doi: 10.3390/10020508.
9
Novel modified purine bases and nucleosides: new methodologies of synthesis and biological activity.新型修饰嘌呤碱基和核苷：合成新方法及生物活性
Nucleic Acids Symp Ser (Oxf). 2005(49):29-30. doi: 10.1093/nass/49.1.29.
10
Copper-catalyzed synthesis of purine-fused polycyclics.铜催化的嘌呤稠合多环化合物的合成。
Org Lett. 2012 Sep 7;14(17):4494-7. doi: 10.1021/ol301848v. Epub 2012 Aug 17.

引用本文的文献

1
Recent Advances in the Synthesis of Acyclic Nucleosides and Their Therapeutic Applications.环状核苷及其类似物的合成研究进展
Top Curr Chem (Cham). 2024 Oct 23;382(4):34. doi: 10.1007/s41061-024-00476-7.
2
Recent Synthesis of Nucleoside Phosphonate Analogs Using Olefin Cross-metathesis.近期利用烯烃交叉复分解反应合成核苷膦酸类似物
Curr Med Chem. 2024 Apr 30. doi: 10.2174/0109298673280546240106123000.
3
Expedient synthesis and biological evaluation of alkenyl acyclic nucleoside phosphonate prodrugs.烯基非环核苷膦酸酯前药的简便合成与生物评价。
Bioorg Med Chem. 2018 Jul 23;26(12):3596-3609. doi: 10.1016/j.bmc.2018.05.034. Epub 2018 May 23.
4
Synthesis and Biological Evaluation of Novel Hybrid Molecules Containing Purine, Coumarin and Isoxazoline or Isoxazole Moieties.含嘌呤、香豆素及异恶唑啉或异恶唑部分的新型杂合分子的合成与生物学评价
Open Med Chem J. 2017 Nov 30;11:196-211. doi: 10.2174/1874104501711010196. eCollection 2017.