Saladino Raffaele, Ciambecchini Umberto, Crestini Claudia, Costanzo Giovanna, Negri Rodolfo, Di Mauro Ernesto
INFM, Dipartimento A.B.A.C. Università della Tuscia, Via San Camillo De Lellis 01100 Viterbo, Italy.
Chembiochem. 2003 Jun 6;4(6):514-21. doi: 10.1002/cbic.200300567.
A novel one-pot TiO2-catalyzed synthesis of nucleobases and acyclonucleosides from formamide is reported. Since formamide can be formed under prebiotic conditions, these reactions have implications for the origin of life. While a number of purine derivatives have been found as products of non-TiO2-catalyzed reactions, important compounds that would not otherwise occur (namely, thymine, 5-hydroxymethyluracil, and acyclonucleosides) are formed in acceptable yields by TiO2-catalyzed reactions. Moreover, TiO2 selectively affects the rates of degradation of nucleobases, as single units and when embedded in polynucleotides.
报道了一种新型的一锅法，即二氧化钛催化由甲酰胺合成核碱基和无环核苷。由于甲酰胺可以在益生元条件下形成，这些反应对生命起源具有重要意义。虽然已发现许多嘌呤衍生物是非二氧化钛催化反应的产物，但二氧化钛催化反应能以可接受的产率生成一些原本不会出现的重要化合物（即胸腺嘧啶、5-羟甲基尿嘧啶和无环核苷）。此外，二氧化钛会选择性地影响核碱基作为单个单元以及嵌入多核苷酸时的降解速率。
