高采食量会增加美洲水貂（Neovison vison）脂肪肝的严重程度，而长链 n-3 多不饱和脂肪酸可能具有改善作用。
High feeding intensity increases the severity of fatty liver in the American mink (Neovison vison) with potential ameliorating role for long-chain n-3 polyunsaturated fatty acids.
机构信息
Department of Plant and Animal Sciences, Faculty of Agriculture, Dalhousie University, P,O, Box 550, B2N 5E3 Truro, NS, Canada.
出版信息
Acta Vet Scand. 2014 Jan 16;56(1):5. doi: 10.1186/1751-0147-56-5.
BACKGROUND
Rapid body fat mobilization, obesity, and an inadequate supply of n-3 polyunsaturated fatty acids (PUFA) have been suggested to play roles in the etiology of fatty liver in the American mink (Neovison vison). This study examined the effects of feeding intensity and dietary fat source on fatty liver induced by fasting. In a multi-factorial design, 3 different fat sources (herring oil, rich in n-3 PUFA, soya oil, rich in n-6 PUFA, and canola oil, rich in n-9 monounsaturated fatty acids) were fed to mink at a low and high feeding intensity for 10 weeks, followed by an overnight or a 5-day fasting treatment to induce fatty liver.
RESULTS
Fasting led to the development of fatty liver with increased severity in the mink fed at the high feeding intensity. The herring oil diet, high in long-chain n-3 PUFA, was found to decrease the severity of fatty liver in the mink at the high feeding intensity.
CONCLUSION
Preventing excessive weight gain and increasing dietary intake of n-3 long-chain PUFA may help prevent excessive lipid accumulation during prolonged periods of fasting or inappetence by promoting hepatic fatty acid oxidation.
背景
快速体脂动员、肥胖和 n-3 多不饱和脂肪酸 (PUFA) 供应不足被认为在美洲水貂（Neovison vison）的脂肪肝发病机制中起作用。本研究检查了喂养强度和饮食脂肪来源对禁食引起的脂肪肝的影响。在多因素设计中，3 种不同的脂肪来源（富含 n-3 PUFA 的鲱鱼油、富含 n-6 PUFA 的大豆油和富含 n-9 单不饱和脂肪酸的菜籽油）以低和高喂养强度喂养水貂 10 周，然后进行过夜或 5 天禁食处理以诱导脂肪肝。
结果
禁食导致高脂肪强度喂养的水貂发生脂肪肝，并使病情加重。富含长链 n-3 PUFA 的鲱鱼油饮食被发现可降低高脂肪强度喂养水貂的脂肪肝严重程度。
结论
预防体重过度增加和增加 n-3 长链 PUFA 的饮食摄入可能有助于通过促进肝脂肪酸氧化来预防长时间禁食或食欲不振期间的脂质过度积累。
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