未服用抗精神病药物的精神分裂症患者的代谢综合征：来自三项印度研究的数据汇总分析
Metabolic syndrome in antipsychotic naïve patients with schizophrenia: pooled analysis of data from three Indian studies.
作者信息
Grover Sandeep, Nebhinani Naresh, Padmavati Ramachandran, Chadda Rakesh K, Tirupati Srinivasan, Pallava Abhishek
机构信息
Postgraduate Institute of Medical Education and Research, Chandigarh.
All India Institute of Medical Sciences, Jodhpur.
出版信息
Early Interv Psychiatry. 2015 Oct;9(5):357-62. doi: 10.1111/eip.12117. Epub 2014 Jan 20.
AIM
This study aimed to assess the prevalence of metabolic syndrome (MS) and subthreshold MS in antipsychotic naïve patients with schizophrenia by pooling the data from three different centres in India.
METHODS
One hundred thirty-seven antipsychotic naïve patients with schizophrenia were evaluated for MS using common criteria for clinical diagnosis.
RESULTS
Twenty-six patients (19%) met consensus criteria. Additionally, 56 patients (40.9%) fulfilled one criterion and 32 patients (23.3%) fulfilled two criteria of MS out of five criteria.
CONCLUSION
One-fifth of antipsychotic naïve patients with schizophrenia had MS and another two-third had at least one metabolic abnormality. Awareness of such a high risk is vitally important for rational selection of antipsychotic medications as well as effective implementation of preventive measures.
目的
本研究旨在通过汇总印度三个不同中心的数据，评估未使用过抗精神病药物的精神分裂症患者中代谢综合征（MS）和亚阈值MS的患病率。
方法
使用临床诊断的通用标准对137例未使用过抗精神病药物的精神分裂症患者进行MS评估。
结果
26例患者（19%）符合共识标准。此外，在五项标准中，56例患者（40.9%）符合一项标准，32例患者（23.3%）符合两项标准。
结论
五分之一未使用过抗精神病药物的精神分裂症患者患有MS，另外三分之二至少有一种代谢异常。认识到如此高的风险对于合理选择抗精神病药物以及有效实施预防措施至关重要。
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