Department of Research, Weill Cornell Medicine - Qatar, Doha, Qatar.
Department of Psychiatry, Rumailah Hospital, Hamad Medical Corporation, Doha, Qatar.
BMC Psychiatry. 2018 Mar 27;18(1):81. doi: 10.1186/s12888-018-1662-6.
Metabolic abnormalities are common in patients maintained on antipsychotics. These abnormalities increase the risk of cardiovascular diseases and mortality in this population. The aim of this study is to assess the prevalence of metabolic syndrome (MetS) in subjects maintained on antipsychotics relative to controls in Qatar, and to assess the factors contributing to the development of MetS.
A cross sectional design was used to collect data and fasting blood samples from subjects maintained on antipsychotics for at least six months (n = 112) and from a control group (n = 114). The groups were compared in regard to prevalence of MetS, and multiple regression analysis was used to determine the risk factors in each group.
The two groups (antipsychotics vs. control) were similar in regard to age (35.73 ± 10.28 vs. 35.73 ± 8.16 years) and gender ratio. The MetS was higher among the subjects on antipsychotics, but this difference did not reach statistical significance. Blood pressure (BP) was significantly higher in the antipsychotics group and BMI was the major risk factor to develop MetS in this group.
The prevalence of MetS in both groups is high and mostly attributed to obesity and high BP. Public health interventions are needed to address this major health problem overall. Larger studies are needed to further assess the impact of antipsychotics and mental illness on the development of MetS.
代谢异常在服用抗精神病药物的患者中很常见。这些异常会增加该人群患心血管疾病和死亡的风险。本研究旨在评估在卡塔尔，与对照组相比，服用抗精神病药物的受试者代谢综合征（MetS）的患病率，并评估导致 MetS 发展的因素。
采用横断面设计收集至少服用抗精神病药物六个月的受试者（n=112）和对照组（n=114）的空腹血样和数据。比较两组 MetS 的患病率，并对每组进行多元回归分析，以确定危险因素。
两组（抗精神病药物组与对照组）在年龄（35.73±10.28 岁与 35.73±8.16 岁）和性别比例方面相似。抗精神病药物组的 MetS 发生率较高，但差异无统计学意义。抗精神病药物组的血压（BP）明显较高，而 BMI 是该组发生 MetS 的主要危险因素。
两组的 MetS 患病率都很高，主要归因于肥胖和高血压。需要采取公共卫生干预措施来解决这一主要健康问题。需要更大的研究来进一步评估抗精神病药物和精神疾病对 MetS 发展的影响。
