[口腔扁平苔藓病损中分泌球蛋白家族2A成员2的表达]
[Expression of secretoglobin family 2A member 2 in oral lichen planus lesions].
作者信息
Tao Xiao-an, Xiao Jian-yong, Zeng Qi, Cheng Bin
机构信息
Department of Oral Medicine,Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University & Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China.
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出版信息
Zhonghua Kou Qiang Yi Xue Za Zhi. 2013 Oct;48(10):606-9.
OBJECTIVE
To examine the expression of secretoglobin family 2A member 2 (SCGB2A2) (mammaglobin A, MGB1) in oral lichen planus (OLP) lesions.
METHODS
Sixteen OLP patients and 10 healthy controls were included in this study. The real time reverse transcription-PCR (RT-PCR), Western blotting and immunohistochemistry (IHC) were used to determine the mRNA and protein of SCGB2A2.
RESULTS
Compared with healthy controls (0.48 ± 0.09), the expression of SCGB2A2 protein in OLP lesions significantly increased (1.02 ± 0.11) (P < 0.05).However, the mRNA level of SCGB2A2 in lesions was significantly lower than that in controls (P < 0.05).
CONCLUSIONS
These results suggest that SCGB2A2 may be involved in pathogenesis of OLP.
目的
检测分泌球蛋白家族2A成员2（SCGB2A2）（乳腺珠蛋白A，MGB1）在口腔扁平苔藓（OLP）病变中的表达。
方法
本研究纳入了16例OLP患者和10名健康对照者。采用实时逆转录聚合酶链反应（RT-PCR）、蛋白质印迹法和免疫组织化学（IHC）检测SCGB2A2的mRNA和蛋白质。
结果
与健康对照者（0.48±0.09）相比，OLP病变中SCGB2A2蛋白的表达显著增加（1.02±0.11）（P<0.05）。然而，病变中SCGB2A2的mRNA水平显著低于对照者（P<0.05）。
结论
这些结果表明SCGB2A2可能参与OLP的发病机制。
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