Ohsugi K, Adachi K, Mukoyama M, Ando K
National Institute of Neuroscience, Tokyo, Japan.
Neurosci Lett. 1987 Aug 31;79(3):351-4. doi: 10.1016/0304-3940(87)90458-7.
Indoleamine metabolism was determined by high-performance liquid chromatography with electrochemical detection in the cervical spinal cord of patients with amyotrophic lateral sclerosis (ALS) and controls with non-neurological diseases. The concentrations of 5-hydroxytryptamine (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) were the highest in the ventral horn compared with other regions of the spinal cord both in ALS and controls. There was no significant change in the concentration of 5-HT in any region of the spinal cord between ALS and controls. In addition, the concentration of 5-HIAA in ALS was lower than that in controls, however, no statistical significance was observed.
采用高效液相色谱-电化学检测法测定肌萎缩侧索硬化症（ALS）患者和非神经疾病对照者颈段脊髓中的吲哚胺代谢情况。在ALS患者和对照者中，与脊髓其他区域相比，腹角中5-羟色胺（5-HT）和5-羟吲哚乙酸（5-HIAA）的浓度最高。ALS患者和对照者脊髓任何区域的5-HT浓度均无显著变化。此外，ALS患者中5-HIAA的浓度低于对照者，但未观察到统计学意义。
