Fujita K, Nagata Y, Honda M
Department of Physiology, School of Medicine, Fujita Health University.
Rinsho Shinkeigaku. 1993 Sep;33(9):985-7.
We analysed free amino acid contents in anterior horn, posterior horn, lateral column and posterior column of the spinal cord transections from autopsied cases of amyotrophic lateral sclerosis (ALS), and compared the results with those from non-ALS cases. Content of free glutamate (Glu), and aspartate (Asp) was reduced significantly not only in the lateral portion where pyramidal tracts run through but also in other portions of cervical cords of ALS cases. Contents of glycine, gamma-aminobutyric acid and taurine were not different between ALS and non-ALS cervical cords. The results suggest that some metabolic disorders of these excitatory amino acid transmitter candidates may exist in ALS spinal cord.
我们分析了肌萎缩侧索硬化症（ALS）尸检病例脊髓横切片前角、后角、外侧柱和后柱中的游离氨基酸含量，并将结果与非ALS病例进行了比较。不仅在锥体束穿过的外侧部分，而且在ALS病例颈髓的其他部分，游离谷氨酸（Glu）和天冬氨酸（Asp）的含量均显著降低。甘氨酸、γ-氨基丁酸和牛磺酸的含量在ALS和非ALS颈髓之间没有差异。结果表明，ALS脊髓中可能存在这些兴奋性氨基酸递质候选物的一些代谢紊乱。
