Donnelly J J, Sakla A A, Hill D E, Lok J B, Khatami M, Rockey J H
Department of Ophthalmology, Scheie Eye Institute, School of Medicine, University of Pennsylvania, Philadelphia.
Ophthalmic Res. 1987;19(3):129-36. doi: 10.1159/000265484.
Subconjunctivally injected Onchocerca lienalis microfilariae (Mf) migrate into the guinea pig cornea, resulting, when the microfilariae die, in punctate stromal opacities resembling those of human onchocerciasis. Administration of diethylcarbamazine citrate (DEC-C) following subconjunctival injection of Mf increased the proportion of dead Mf in the cornea, the number of punctate opacities and the extent of peripheral corneal neovascularization. Betamethasone (a synthetic steroid) and lodoxamide tromethamine (an inhibitor of mediator release from mast cells) inhibited the formation of punctate opacities. Chlorpheniramine maleate and cimetidine (H1 and H2 histamine receptor antagonists), given together, did not alter the formation of punctate opacities but inhibited the peripheral corneal neovascularization. These observations suggest that mast cell mediators other than histamine may be of importance in the formation of the corneal punctate opacities.
结膜下注射链尾盘尾丝虫微丝蚴（Mf）后，其会迁移至豚鼠角膜，当微丝蚴死亡时，会导致点状基质混浊，类似于人类盘尾丝虫病的表现。结膜下注射Mf后给予枸橼酸乙胺嗪（DEC-C），可增加角膜中死亡Mf的比例、点状混浊的数量以及角膜周边新生血管形成的程度。倍他米松（一种合成类固醇）和洛度沙胺 tromethamine（肥大细胞介质释放抑制剂）可抑制点状混浊的形成。马来酸氯苯那敏和西咪替丁（H1和H2组胺受体拮抗剂）联合使用，虽不改变点状混浊的形成，但可抑制角膜周边新生血管形成。这些观察结果表明，除组胺外，肥大细胞介质可能在角膜点状混浊的形成中起重要作用。
