Department of Internal Medicine, University of Texas Medical Branch, 301 University Blvd, Galveston, TX.
Department of Internal Medicine, University of Texas Medical Branch, 301 University Blvd, Galveston, TX.
Explore (NY). 2014 Jan-Feb;10(1):44-52. doi: 10.1016/j.explore.2013.10.001. Epub 2013 Oct 17.
The gastrointestinal (GI) dysmotility of systemic sclerosis (SSc, scleroderma) patients requires careful evaluation and intervention. The lack of effective prokinetic drugs motivate researchers to search for alternative treatments.
We present an overview of the pathophysiology of SSc GI dysmotility and the advances in its management, with particular focus on acupuncture-related modalities and innovative therapies.
Original research articles were identified based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guideline methodology. We have searched the MEDLINE database using Medical Subject Heading (MeSH) for all English and non-English articles with an English abstract from 2005 to October 2012.
Only four original articles of various study designs were found studying Complementary and Alternative Medicine (CAM) therapies for SSc patients. Despite the small patient study numbers, CAM treatments, acupressure, and transcutaneous electroacupuncture, showed self-reported and physiologic evidence of improvement of GI functioning and/or symptoms in SSc patients.
CAM therapies include experimental modalities with the potential to offer relief of symptoms from GI dysmotility. Larger studies are needed to investigate their optimal use in patient subsets to tailor therapies to patient needs.
系统性硬化症（SSc，硬皮病）患者的胃肠道（GI）动力障碍需要仔细评估和干预。缺乏有效的促动力药物促使研究人员寻找替代治疗方法。
我们介绍了 SSc GI 动力障碍的病理生理学概述及其治疗进展，特别关注与针灸相关的模式和创新疗法。
根据系统评价和荟萃分析的首选报告项目（PRISMA）指南方法，确定了原始研究文章。我们使用医学主题词（MeSH）在 MEDLINE 数据库中搜索了所有 2005 年至 2012 年 10 月的英文和非英文文章，并有英文摘要。
仅发现了四项研究设计不同的原始文章，研究了针对 SSc 患者的补充和替代医学（CAM）疗法。尽管患者的研究数量较少，但 CAM 治疗、穴位按压和经皮电针治疗显示出自我报告和生理学证据，表明 GI 功能和/或症状得到改善。
CAM 疗法包括具有缓解 GI 动力障碍症状潜力的实验模式。需要更大规模的研究来调查它们在患者亚组中的最佳应用，以根据患者的需求定制治疗方法。
