Department of Chemistry, Graduate School of Science and Engineering, Tokyo Metropolitan University, Tokyo 192-0397, Japan.
Raymond and Beverly Sackler School of Physics and Astronomy, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel.
Adv Colloid Interface Sci. 2014 Jun;208:34-46. doi: 10.1016/j.cis.2013.12.003. Epub 2013 Dec 16.
Ever since the raft model for biomembranes has been proposed, the traditional view of biomembranes based on the fluid-mosaic model has been altered. In the raft model, dynamical heterogeneities in multi-component lipid bilayers play an essential role. Focusing on the lateral phase separation of biomembranes and vesicles, we review some of the most relevant research conducted over the last decade. We mainly refer to those experimental works that are based on physical chemistry approach, and to theoretical explanations given in terms of soft matter physics. In the first part, we describe the phase behavior and the conformation of multi-component lipid bilayers. After formulating the hydrodynamics of fluid membranes in the presence of the surrounding solvent, we discuss the domain growth-law and decay rate of concentration fluctuations. Finally, we review several attempts to describe membrane rafts as two-dimensional microemulsion.
自从生物膜的筏模型被提出以来，基于流动镶嵌模型的传统生物膜观点已经发生了改变。在筏模型中，多组分脂质双层中的动力学非均相起着至关重要的作用。本文聚焦于生物膜和囊泡的侧向相分离，综述了过去十年中一些最相关的研究。我们主要参考了那些基于物理化学方法的实验工作，并根据软物质物理给出了理论解释。在第一部分中，我们描述了多组分脂质双层的相行为和构象。在提出了存在周围溶剂时流体膜的流体动力学之后，我们讨论了浓度涨落的畴生长律和衰减率。最后，我们综述了几种将膜筏描述为二维微乳液的尝试。
