Berkenbosch F, van Oers J, del Rey A, Tilders F, Besedovsky H
Department of Pharmacology, Medical Faculty, Free University, Amsterdam, the Netherlands.
Science. 1987 Oct 23;238(4826):524-6. doi: 10.1126/science.2443979.
Intraperitoneal administration of human recombinant interleukin-1 (IL-1) to rats can increase blood levels of corticosterone and adrenocorticotropic hormone (ACTH). The route by which IL-1 affects pituitary-adrenal activity is unknown. That the IL-1-induced pituitary-adrenal activation involves an increased secretion of corticotropin-releasing factor (CRF) is indicated by three lines of evidence. First, immunoneutralization of CRF markedly attenuated the IL-1-induced increase of ACTH blood levels. Second, after blockade of fast axonal transport in hypothalamic neurons by colchicine, IL-1 administration decreased the CRF immunostaining in the median eminence, indicating an enhanced release of CRF in response to IL-1. Third, IL-1 did not stimulate ACTH release from primary cultures of anterior pituitary cells. These data further support the notion of the existence of an immunoregulatory feedback circuit between the immune system and the brain.
给大鼠腹腔注射人重组白细胞介素-1（IL-1）可提高皮质酮和促肾上腺皮质激素（ACTH）的血液水平。IL-1影响垂体-肾上腺活动的途径尚不清楚。有三条证据表明，IL-1诱导的垂体-肾上腺激活涉及促肾上腺皮质激素释放因子（CRF）分泌增加。第一，CRF的免疫中和显著减弱了IL-1诱导的ACTH血液水平升高。第二，用秋水仙碱阻断下丘脑神经元的快速轴突运输后，注射IL-1会降低正中隆起处的CRF免疫染色，表明对IL-1反应时CRF释放增强。第三，IL-1不会刺激垂体前叶细胞原代培养物释放ACTH。这些数据进一步支持了免疫系统和大脑之间存在免疫调节反馈回路这一观点。
