Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, University of Texas at Austin, 2506 Speedway, Stop A5000, Austin, TX 78712-1191, USA.
Department of Molecular Biosciences, Institute for Cellular and Molecular Biology, University of Texas at Austin, 2506 Speedway, Stop A5000, Austin, TX 78712-1191, USA.
Cell Host Microbe. 2014 Jan 15;15(1):3-5. doi: 10.1016/j.chom.2013.12.012.
Necroptosis has emerged as an important facet of both host defense and inflammatory disease. In this issue, Rodrigue-Gervais et al. (2014) demonstrate a role for the cell death regulator cIAP2 in maintaining lung homeostasis during influenza infection. Loss of cIAP2 promotes necroptosis of lung tissues, leading to host death.
细胞程序性坏死（Necroptosis）已成为宿主防御和炎症性疾病的一个重要方面。在本期中，Rodrigue-Gervais 等人（2014）证明了细胞死亡调节剂 cIAP2 在流感感染期间维持肺内稳态中的作用。cIAP2 的缺失会促进肺组织的程序性细胞坏死，导致宿主死亡。
