González-Lara L, Gómez-Bernal S, Vázquez-López F, Vivanco-Allende B
Servicio de Dermatología, Hospital Universitario Central de Asturias, Oviedo, España.
Servicio de Dermatología, Hospital Universitario Central de Asturias, Oviedo, España.
Actas Dermosifiliogr. 2014 Jul-Aug;105(6):e39-43. doi: 10.1016/j.ad.2013.09.014. Epub 2014 Jan 17.
Acquired perforating dermatosis (APD) is an uncommon disease characterized by lesions exhibiting transepidermal elimination of collagen or elastic fibers. APD affects adults and is associated with systemic diseases, mainly diabetes mellitus and renal failure. We present 8 cases of APD. Seven patients had concomitant diabetes mellitus with or without chronic renal failure, and 1 had alcoholic cirrhosis. In the patients with chronic renal failure, the onset of APD coincided with transient worsening of renal function. The mean increase in creatinine concentrations above baseline was 1.14mg/dL. Acute deterioration of renal function may be involved in APD. Further studies are needed to investigate this association.
获得性穿通性皮病（APD）是一种罕见疾病，其特征为病变表现出胶原蛋白或弹性纤维的经表皮排出。APD影响成年人，且与全身性疾病相关，主要是糖尿病和肾衰竭。我们报告8例APD。7例患者伴有糖尿病，有或无慢性肾衰竭，1例有酒精性肝硬化。在慢性肾衰竭患者中，APD的发病与肾功能的短暂恶化同时出现。肌酐浓度较基线的平均升高为1.14mg/dL。肾功能的急性恶化可能与APD有关。需要进一步研究来调查这种关联。
