Departament de Química Orgànica, Facultat de Química, Universitat de València, C/ Dr. Moliner 50, 46100-Burjassot, Spain.
Chem Commun (Camb). 2014 Mar 4;50(18):2275-8. doi: 10.1039/c3cc48508k. Epub 2014 Jan 17.
The first enantioselective conjugate alkynylation of β-trifluoromethyl α,β-enones using terminal alkynes and a taniaphos-Cu(I) complex as catalyst is described. Ketones bearing a trifluoromethylated propargylic chiral centre in the β-position were obtained with good yields and high enantiomeric excesses (up to 99%).
本文描述了首例使用末端炔烃和手性双膦配体-铜（I）配合物作为催化剂的β-三氟甲基-α,β-烯酮的对映选择性共轭炔基化反应。β-位具有三氟甲基取代的炔丙基手性中心的酮以良好的收率和高对映选择性（高达 99%）得到。
