Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Japan.
Angew Chem Int Ed Engl. 2012 May 14;51(20):4959-62. doi: 10.1002/anie.201201278. Epub 2012 Apr 4.
Ether way: the cinchona-alkaloid-catalyzed title reaction was achieved in high yields with high to excellent ee values for the first time, and affords key intermediates for the biologically important 2 having a trifluoromethylated all-carbon quaternary chiral center. Ether-type catalysts (1) are more efficient in this transformation than the conventional hydroxy analogues.
金鸡纳生物碱催化的标题反应首次以高产率和高至优异的对映选择性实现，并提供了具有重要生物活性的 2 的关键中间体，其具有三氟甲基化的全碳季碳手性中心。与传统的羟基类似物相比，醚型催化剂 (1) 在这种转化中更有效。
