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人眼睑中的默克尔细胞分布。

Merkel cell distribution in the human eyelid.

作者信息

May C A, Osterland I

机构信息

Dresden University of Technology.

出版信息

Eur J Histochem. 2013 Oct 30;57(4):e33. doi: 10.4081/ejh.2013.e33.

DOI:10.4081/ejh.2013.e33
PMID:24441186
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3896035/
Abstract

Although Merkel cell carcinoma of the eye lid is reported frequently in the literature, only limited information exists about the distribution of Merkel cells in this tissue. Therefore, serial sections of 18 human cadaver eye lids (donors ages ranging between 63 and 97 years) were stained for cytokeratin 20 in various planes. The overall appearance of Merkel cells in these samples was low and mainly located in the outer root layer of the cilia hair follicles. Merkel cells were more frequent in the middle, and almost not detectable at the nasal and temporal edges. The localization is in accordance with that of Merkel cell carcinoma, but concerning the scarce appearance within this adulthood group, a specific physiological role of these cells in the eye lid is difficult to establish.

摘要

尽管眼睑默克尔细胞癌在文献中经常被报道，但关于默克尔细胞在该组织中的分布信息却很有限。因此，对18例人类尸体眼睑（供体年龄在63至97岁之间）的连续切片在不同平面进行细胞角蛋白20染色。这些样本中默克尔细胞的总体外观较少，主要位于睫毛毛囊的外根层。默克尔细胞在中间部分更为常见，在鼻侧和颞侧边缘几乎检测不到。其定位与默克尔细胞癌一致，但考虑到在这个成年组中其出现稀少，这些细胞在眼睑中的特定生理作用难以确定。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a23d/3896035/cda4f2311a1c/ejh-2013-4-e33-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a23d/3896035/cfa31ff107e1/ejh-2013-4-e33-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a23d/3896035/cda4f2311a1c/ejh-2013-4-e33-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a23d/3896035/cfa31ff107e1/ejh-2013-4-e33-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a23d/3896035/cda4f2311a1c/ejh-2013-4-e33-g002.jpg

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本文引用的文献

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Merkel cell carcinoma: a virus-induced human cancer. Merkel 细胞癌：一种由病毒引起的人类癌症。
Annu Rev Pathol. 2012;7:123-44. doi: 10.1146/annurev-pathol-011110-130227. Epub 2011 Sep 13.
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Eyelid and periocular cutaneous Merkel cell carcinoma (aka. neuroendocrine or trabecular carcinoma).眼睑及眼周皮肤默克尔细胞癌（又称神经内分泌癌或小梁癌）。
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左眼睑 Merkel 细胞癌伴左下颌下淋巴结转移：一例报告及简要综述
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Merkel-like cell distribution in the epithelium of the human vagina. An immunohistochemical and TEM study.人阴道上皮中默克尔细胞样细胞的分布：一项免疫组织化学和透射电子显微镜研究
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Eur J Cell Biol. 2005 Mar;84(2-3):259-71. doi: 10.1016/j.ejcb.2004.12.023.
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