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皮下注射低分子量肝素后出现坏疽性脓皮病样皮肤改变。

Pyoderma gangrenosum-like skin changes after subcutaneous administration of low molecular weight heparin.

作者信息

Sobieszczańska Małgorzata, Tubek Sławomir, Kura Ilona

机构信息

Department of Pathophysiology; Wroclaw Medical University; Wroclaw, Poland.

Department of Internal Diseases; Opole Voivodship Hospital; Opole, Poland.

出版信息

Hum Vaccin Immunother. 2014;10(4):968-9. doi: 10.4161/hv.27699. Epub 2014 Jan 17.

Abstract

In the present report, we would like to comment a case of patient with diabetes mellitus type 2 manifesting the rare complication of heparin subcutaneous administration in a form of pyoderma gangrenosum-like skin changes which were induced probably by an immune-modulating activity of heparin.

摘要

在本报告中,我们想评论一例2型糖尿病患者,该患者出现了肝素皮下注射罕见的并发症,表现为坏疽性脓皮病样皮肤改变,这可能是由肝素的免疫调节活性引起的。

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本文引用的文献

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Cutaneous microangiopathic thrombosis complicated by pyoderma gangrenosum in post-cardiac surgery heparin-induced thrombocytopaenia.
Heart Lung Circ. 2009 Aug;18(4):307-10. doi: 10.1016/j.hlc.2007.12.007. Epub 2008 Mar 28.
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Anticoagulant-responsive pyoderma gangrenosum associated with an underlying prothrombotic dysfibrinogenaemia.
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Abdominal wall ulceration and mucinosis secondary to recombinant human interferon-beta-1b.
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