Pratusevich V R, Zykov V S, Mukumov M R
Biofizika. 1987 Jul-Aug;32(4):668-72.
An assessment of the ionic action mechanism of cardiotropic substances with the aid of a mathematical model for excitation-contraction coupling in myocardium is proved to be possible. The technique developed consists in the model parameter identification from the experimental data on electrical and mechanical activity of myocardial strip. The validity of the technique is tested using the known mechanism drugs. An example is given of analysis by the technique suggested of the action mechanism of diltiazem on the rat papillary muscle.
事实证明，借助心肌兴奋 - 收缩偶联的数学模型来评估强心物质的离子作用机制是可行的。所开发的技术包括根据心肌条电活动和机械活动的实验数据进行模型参数识别。使用已知作用机制的药物对该技术的有效性进行了测试。给出了一个使用所建议的技术分析地尔硫卓对大鼠乳头肌作用机制的例子。
