Mukumov M R, Pratusevitch V R, Khodorov B I
Gen Physiol Biophys. 1986 Jun;5(3):259-71.
The hypothesis that intracellular calcium stores play an essential role in determining force-frequency relationships of frog myocardium was tested quantitatively. A simplified mathematical model of excitation-contraction coupling in frog heart muscle was developed and its behaviour under various patterns of stimulation was analysed by means of computer simulation. The model represents a system of ordinary differential equations for individual fluxes within the cell Ca2+-recirculation system and includes a one-compartmental intracellular pool as opposed to the two-compartmental structure of the mammalian sarcoplasmic reticulum (Kaufmann et al. 1974). The behaviour of the model is consistent with available experimental data concerning the basic rhythm-inotropic characteristics of amphibian myocardium and offers some evidence in favour of the basic concept. Within the framework of the proposed model the staircase phenomena in amphibia were accounted for and the impact of different intracellular Ca-movements on the resulting contractile response and rhythm-inotropic phenomena was elucidated.
关于细胞内钙储备在决定青蛙心肌力量-频率关系中起关键作用这一假说进行了定量测试。构建了青蛙心肌兴奋-收缩偶联的简化数学模型，并通过计算机模拟分析了其在各种刺激模式下的行为。该模型代表了细胞内Ca2+再循环系统中各个通量的常微分方程组，并且包含一个单房室的细胞内池，与哺乳动物肌浆网的双房室结构不同（考夫曼等人，1974年）。该模型的行为与有关两栖动物心肌基本节律-变力特性的现有实验数据一致，并为基本概念提供了一些证据。在所提出模型的框架内，解释了两栖动物中的阶梯现象，并阐明了不同细胞内钙运动对所产生的收缩反应和节律-变力现象的影响。
