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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Bobik A, Weissberg P L, Little P J

Clinical Research Unit, Alfred Hospital, Prahran, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1987 Mar;14(3):191-5. doi: 10.1111/j.1440-1681.1987.tb00374.x.

The effects of Na-H antiport inhibitors on sodium influx, intracellular pH and Na,K-pump activity were examined in vascular smooth muscle from rats. 2. Amiloride and 5-(N-ethyl-N-isopropyl)amiloride inhibited Na accumulation following inhibition of the Na,K-pump. 3. Inhibition of Na influx was associated with a reduction in basal Na,K-pump activity and intracellular pH. 4. It is concluded that a Na-H antiport system in vascular smooth muscle regulates Na influx rate, contributes to intracellular pH regulation and influences basal levels of Na,K-pump activity.

Bobik A, Weissberg P L, Little P J

Clinical Research Unit, Alfred Hospital, Prahran, Victoria, Australia.

Clin Exp Pharmacol Physiol. 1987 Mar;14(3):191-5. doi: 10.1111/j.1440-1681.1987.tb00374.x.

The effects of Na-H antiport inhibitors on sodium influx, intracellular pH and Na,K-pump activity were examined in vascular smooth muscle from rats. 2. Amiloride and 5-(N-ethyl-N-isopropyl)amiloride inhibited Na accumulation following inhibition of the Na,K-pump. 3. Inhibition of Na influx was associated with a reduction in basal Na,K-pump activity and intracellular pH. 4. It is concluded that a Na-H antiport system in vascular smooth muscle regulates Na influx rate, contributes to intracellular pH regulation and influences basal levels of Na,K-pump activity.