Miki Yasuo, Mori Fumiaki, Tanji Kunikazu, Kurotaki Hidekachi, Kakita Akiyoshi, Takahashi Hitoshi, Wakabayashi Koichi
Department of Neuropathology, Institute of Brain Science, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Neuropathology. 2014 Aug;34(4):386-91. doi: 10.1111/neup.12104. Epub 2014 Jan 20.
There is little immunohistochemical information about the early stage of Pick body formation, due to the extremely limited opportunities of studying Pick's disease at the incipient or subclinical stage. We report a 62-year-old man without any clinical manifestations of Pick's disease, who died of B-cell lymphoma of the brainstem. Post mortem examination revealed many Pick bodies without obvious neuronal loss mainly in the left frontal and temporal lobes. Three brains of patients with typical Pick's disease (disease duration: 7, 11 and 16 years) were also examined. Pick bodies were immunopositive for phosphorylated tau and 3-repeat tau, and less consistently for p62 in both incipient and typical cases. In the incipient case, borderline positivity for ubiquitin was evident in only a few Pick bodies, whereas in the typical cases many Pick bodies showed obvious positivity for ubiquitin. These findings suggest that Pick bodies are rarely ubiquitinated in the early stage of Pick body formation.
由于在疾病初期或亚临床阶段研究匹克病的机会极其有限，关于匹克小体形成早期阶段的免疫组化信息很少。我们报告了一名62岁男性，他没有匹克病的任何临床表现，死于脑干B细胞淋巴瘤。尸检发现许多匹克小体，主要位于左额叶和颞叶，无明显神经元丢失。我们还检查了3例典型匹克病患者的大脑（病程分别为7年、11年和16年）。在疾病初期和典型病例中，匹克小体对磷酸化tau蛋白和3重复tau蛋白呈免疫阳性，对p62的免疫阳性则不太一致。在疾病初期病例中，只有少数匹克小体对泛素呈临界阳性，而在典型病例中，许多匹克小体对泛素呈明显阳性。这些发现表明，在匹克小体形成的早期阶段，匹克小体很少被泛素化。
