Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands; European Graduate School of Neuroscience (EURON), Maastricht, The Netherlands.
Department of Neuropsychology and Psychopharmacology, Maastricht University, Maastricht, The Netherlands; European Graduate School of Neuroscience (EURON), Maastricht, The Netherlands.
Neurobiol Learn Mem. 2014 Mar;109:139-43. doi: 10.1016/j.nlm.2014.01.006. Epub 2014 Jan 18.
We examined the temporal profile of pharmacologically enhanced episodic memory, using the object recognition task. Male Wistar rats were tested at different retention intervals ranging from 1 h to 24 h. The object discrimination performance of all groups (untreated, placebo, drug treatment) gradually decreased up to an interval (8 h). Interestingly, only after this 8 h interval the memory improving effects of vardenafil and rolipram started to emerge. This time-dependent memory performance shows similarities with the Kamin effect. The delayed manifestation of drug-enhanced memory suggests that two separate memory mechanisms are at play, a quick transient form of memory and a more stable memory form that requires several hours to develop. It is important to take this into account when testing treatments intended for long-term memory enhancement.
我们使用物体识别任务来研究药物增强的情景记忆的时间进程。雄性 Wistar 大鼠在从 1 小时到 24 小时的不同潜伏期进行测试。所有组（未处理、安慰剂、药物处理）的物体辨别性能逐渐下降，直到潜伏期（8 小时）。有趣的是，只有在这个 8 小时的潜伏期之后，伐地那非和罗利普兰的记忆改善作用才开始显现。这种时程依赖性的记忆表现与卡明效应相似。药物增强记忆的延迟表现表明存在两种不同的记忆机制，一种是快速短暂的记忆形式，另一种是更稳定的记忆形式，需要几个小时才能发展。在测试旨在增强长期记忆的治疗方法时，这一点非常重要。
