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[因假性胆碱酯酶缺乏导致的残余肌松阻滞——老年患者的首次表现]

[Residual relaxant block due to pseudocholinesterase deficiency - First manifestation in an elderly patient].

作者信息

Zoller Marc, Walther Stefan

出版信息

Anasthesiol Intensivmed Notfallmed Schmerzther. 2014 Jan;49(1):8-11. doi: 10.1055/s-0033-1363907. Epub 2014 Jan 20.

Abstract

Pseudocholinesterase or butyrylcholinesterase (BChE) inactivates the relaxant drugs mivacurium and suxamethonium. A deficiency in plasma activity of this enzyme may result in prolonged muscular paralysis and subsequently the need for an extended duration of mechanical ventilation. We report the case of a 65-year-old patient who was diagnosed with butyrylcholinesterase deficiency for the first time during elective surgery. Neuromuscular monitoring constitutes a central diagnostic asset in ensuring patient safety.

摘要

假性胆碱酯酶或丁酰胆碱酯酶(BChE)可使肌松药米库氯铵和琥珀胆碱失活。该酶血浆活性缺乏可能导致肌肉麻痹时间延长,进而需要延长机械通气时间。我们报告一例65岁患者,其在择期手术期间首次被诊断为丁酰胆碱酯酶缺乏。神经肌肉监测是确保患者安全的核心诊断手段。

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