Lacerte G, Langlois M-F, Doyon M, Brown C, Carpentier A C, Hivert M-F
Centre de recherche clinique Etienne-LeBel, Centre hospitalier universitaire de Sherbrooke, Sherbrooke, QC, Canada.
Horm Metab Res. 2014 May;46(5):354-9. doi: 10.1055/s-0033-1363224. Epub 2014 Jan 20.
The aim of the study was to evaluate the influence of weight gain and changes in adiposity distribution on insulin resistance and circulating adiponectin variations over 4 years in free-living normal weight young adults. In this prospective observational cohort (n=42 women, 18 men), anthropometric measurements and blood samples were collected in the fasting state at baseline and at 4 years. Insulin resistance was estimated using the homeostatic model assessment (HOMA-IR). Circulating adiponectin levels were determined by radioimmunoassay. To investigate increase in adiposity more specifically, subsidiary analyses were performed in a subgroup of individuals (n=31) who gained adiposity over the course of the 4-year follow-up (defined as gain >1% in percent body fat). Regression analyses were performed to adjust for sex, age, parental education, lifestyle, and fitness levels. At baseline, the participants were young adults (age=20.0 years old) in the normal weight range [body mass index (BMI)=22.7 kg/m2 (IQR=21.1-24.4)]. Median change in body fat percentage was +1.4% (IQR=-0.3-3.4; p=0.01) and in waist circumference was +1.2 cm (IQR=-2.6-5.3; p=0.05). In the subgroup of individuals who gained more than 1% body fat, increase in HOMA-IR was associated with an increase in BMI (r=0.44; p=0.01; p<0.01 in fully adjusted model), while decrease in adiponectin levels was associated with an increase in waist circumference (r=-0.38; p=0.03) but this was no longer significant after adjustment for sex and other potential confounders (p=0.14). In a population of young adults, small variations in adiposity within the normal weight range were associated with increase in insulin resistance.
本研究的目的是评估在自由生活的正常体重年轻成年人中，体重增加和肥胖分布变化对胰岛素抵抗以及4年内循环脂联素变化的影响。在这个前瞻性观察队列中（42名女性，18名男性），在基线和4年时的空腹状态下收集人体测量数据和血样。使用稳态模型评估（HOMA-IR）来估计胰岛素抵抗。通过放射免疫测定法测定循环脂联素水平。为了更具体地研究肥胖增加情况，在4年随访期间肥胖增加的个体亚组（n = 31，定义为体脂百分比增加>1%）中进行了辅助分析。进行回归分析以调整性别、年龄、父母教育程度、生活方式和健康水平。基线时，参与者为正常体重范围内的年轻成年人（年龄 = 20.0岁，体重指数（BMI）= 22.7 kg/m²（IQR = 21.1 - 24.4））。体脂百分比的中位数变化为 +1.4%（IQR = -0.3 - 3.4；p = 0.01），腰围的中位数变化为 +1.2 cm（IQR = -2.6 - 5.3；p = 0.05）。在体脂增加超过1%的个体亚组中，HOMA-IR的增加与BMI的增加相关（r = 0.44；p = 0.01；在完全调整模型中p < 0.01），而脂联素水平的降低与腰围的增加相关（r = -0.38；p = 0.03），但在调整性别和其他潜在混杂因素后不再显著（p = 0.14）。在年轻成年人群体中，正常体重范围内肥胖的微小变化与胰岛素抵抗的增加相关。
