Yunker Lars P E, Stoddard Rhonda L, McIndoe J Scott
Department of Chemistry, University of Victoria, P.O. Box 3065, Victoria, BC, V8W3V6, Canada.
J Mass Spectrom. 2014 Jan;49(1):1-8. doi: 10.1002/jms.3303.
Electrospray ionization mass spectrometry (ESI-MS) is a soft ionization technique commonly coupled with liquid or gas chromatography for the identification of compounds in a one-time view of a mixture (for example, the resulting mixture generated by a synthesis). Over the past decade, Scott McIndoe and his research group at the University of Victoria have developed various methodologies to enhance the ability of ESI-MS to continuously monitor catalytic reactions as they proceed. The power, sensitivity and large dynamic range of ESI-MS have allowed for the refinement of several homogenous catalytic mechanisms and could potentially be applied to a wide range of reactions (catalytic or otherwise) for the determination of their mechanistic pathways. In this special feature article, some of the key challenges encountered and the adaptations employed to counter them are briefly reviewed.
电喷雾电离质谱法（ESI-MS）是一种软电离技术，通常与液相或气相色谱联用，用于一次性鉴定混合物中的化合物（例如，合成产生的混合物）。在过去十年中，维多利亚大学的斯科特·麦金杜和他的研究小组开发了各种方法，以提高ESI-MS在催化反应进行过程中连续监测的能力。ESI-MS的强大功能、灵敏度和大动态范围使得几种均相催化机制得以完善，并有可能应用于广泛的反应（催化反应或其他反应）以确定其反应机理途径。在这篇专题文章中，简要回顾了遇到的一些关键挑战以及为应对这些挑战所采用的调整方法。
