Chen F, Zhou J, Xue Y, Yang S, Xiong M, Li Y, Liu Q
Life Sciences School of Hubei University, Wuchang, Wuhan, China.
Wuhan Tuberculosis Dispensary, Qiaokou, Wuhan, China.
Genet Mol Res. 2014 Jan 10;13(1):182-7. doi: 10.4238/2014.January.10.9.
A single nucleotide polymorphism (SNP) in the TNRC9 gene was identified as a breast cancer susceptibility genetic variant in recent genome-wide association studies of women of European ancestry. We investigated whether TNRC9 polymorphisms are associated with risk of breast cancer in Chinese women of the Han nationality. We genotyped the SNPs rs3803662, rs1362548, rs1123428 in 870 women, including 388 breast cancer patients and 482 healthy controls, via the PCR-single strand conformation polymorphism procedure and by sequence detection. We found that the T allele and the TT genotype of the SNP rs38033662 is significantly associated with risk for breast cancer in Chinese Han women; however, no significant association was found for rs1362548 or rs1123428. We conclude that SNP rs3803662 is a putative risk factor for breast cancer in Chinese Han women.
在最近针对欧洲血统女性的全基因组关联研究中，TNRC9基因中的一个单核苷酸多态性（SNP）被确定为乳腺癌易感性基因变异。我们调查了TNRC9基因多态性是否与中国汉族女性的乳腺癌风险相关。我们通过聚合酶链反应-单链构象多态性方法和序列检测，对870名女性（包括388例乳腺癌患者和482名健康对照）的SNP rs3803662、rs1362548、rs1123428进行基因分型。我们发现，SNP rs38033662的T等位基因和TT基因型与中国汉族女性的乳腺癌风险显著相关；然而，rs1362548或rs1123428未发现显著相关性。我们得出结论，SNP rs3803662是中国汉族女性乳腺癌的一个假定风险因素。
