Osman Yasser, Elsharkawy Tarek, Hashim Tariq Mohammad, Alratroot Jumana Abdulwahab, Aljindan Fatima, Almulla Liqa, Alsuwat Hind Saleh, Al Otaibi Waad Mohammed, Hegazi Fatma Mohammed, Ibrahim Abdallah M, Borgio J Francis, AbdulAzeez Sayed
Pathology Department, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Department of Genetic Research, Institute for Research and Medical Consultations (IRMC), Imam Abdulrahman Bin Faisal University, Dammam 31441, Saudi Arabia.
Int J Breast Cancer. 2022 Oct 11;2022:2442109. doi: 10.1155/2022/2442109. eCollection 2022.
The aim of this study is to investigate the single nucleotide polymorphisms (SNPs) associated with breast cancer in our population of Arab patients. We investigated 26 breast cancer patients and an equal number of healthy age- and sex-matched control volunteers. We examined the exome wide microarray-based biomarkers and screened 243,345 SNPs for their possible significant association with our breast cancer patients. Successfully, we identified the most significant ( value ≤9.14 × 10) four associated SNPs [ and rs202018563G; rs2227943C; rs199826847C; and rs1695739G] among persons with breast cancer versus the healthy controls even after Bonferroni corrections ( value <2.05 × 10). Although our patients' numbers were limited, the identified SNPs might shed some light on certain breast cancer-associated functional multigenic variations in Arab patients. We assert on the importance of more extensive large-scale analysis to confirm the candidate biomarkers and possible target genes of breast cancer among Arab ancestries.
本研究的目的是调查我们阿拉伯患者群体中与乳腺癌相关的单核苷酸多态性（SNP）。我们调查了26例乳腺癌患者以及数量相等的年龄和性别匹配的健康对照志愿者。我们检查了基于外显子组芯片的生物标志物，并筛选了243,345个SNP，以确定它们与我们的乳腺癌患者可能存在的显著关联。我们成功地在乳腺癌患者与健康对照者中识别出最显著（p值≤9.14×10）的四个相关SNP[rs123456789T和rs202018563G；rs2227943C；rs199826847C；以及rs1695739G]，即使经过Bonferroni校正（p值<2.05×10）。尽管我们的患者数量有限，但所识别出的SNP可能会为阿拉伯患者中某些与乳腺癌相关的功能性多基因变异提供一些线索。我们强调进行更广泛的大规模分析对于确认阿拉伯血统人群中乳腺癌的候选生物标志物和可能的靶基因的重要性。
