Scuola Internazionale Superiore di Studi Avanzati (SISSA/ISAS), Trieste, Italy.
Adv Exp Med Biol. 2014;805:441-57. doi: 10.1007/978-3-319-02970-2_18.
G-protein coupled receptors (GPCRs) constitute the targets of about 40 % of all the pharmaceutical drugs in the market and, among other functions, a large portion of the family detects odorants and a variety of tastant molecules. Computational techniques are instrumental to understand structure, dynamics and function of the cascades triggered by these receptors. As an example, here we report our own computational work aimed to dissect GPCR molecular mechanisms for chemical senses. The implications of our work for systems biology and for pharmacology are discussed.
G 蛋白偶联受体 (GPCRs) 约占市场上所有药物的 40%，其家族的很大一部分除了其他功能外，还可以检测气味和各种味觉分子。计算技术对于理解这些受体引发的级联反应的结构、动态和功能至关重要。例如，这里我们报告我们自己的旨在剖析化学感觉的 GPCR 分子机制的计算工作。讨论了我们的工作对系统生物学和药理学的意义。
