Scott Erin M, Carter Renee T
Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI.
J Am Anim Hosp Assoc. 2014 Mar-Apr;50(2):112-8. doi: 10.5326/JAAHA-MS-6012. Epub 2014 Jan 20.
Keratomycosis is rarely reported in dogs. The purpose of this study was to review the signalment, clinical characteristics, predisposing factors, and outcome of 11 cases of canine keratomycosis. Medical records of included dogs were reviewed and follow-up information was obtained by re-examination of patients following their initial diagnosis. All 11 patients possessed predisposing factors for fungal keratitis, including an underlying endocrinopathy, pre-existing corneal disease, intraocular surgery, and/or prolonged use of either topical antibiotics or corticosteroids at the time of initial examination. Diagnostic techniques included corneal cytology demonstrating yeast or hyphae in 6 of 11 eyes, and fungal cultures with positive results in 7 of 11 eyes. Fungal organisms isolated included Cladosporium spp. (n = 1), Chrysosporium spp. (n = 1), Curvularia spp. (n = 2), Aspergillus spp. (n = 1), Penicillium spp. (n = 1), and Phialemonium spp. (n = 1). Of the 11 patients, 6 responded to medical management alone. Two resolved after a superficial keratectomy, and three were enucleated due to either endophthalmitis or progression of corneal disease. This study identified potential risk factors for developing fungal keratitis.
犬角膜真菌病在犬类中鲜有报道。本研究旨在回顾11例犬角膜真菌病病例的特征、临床特点、诱发因素及预后情况。对纳入研究的犬只病历进行了回顾，并通过对初诊患者复诊获取随访信息。所有11例患者均有真菌性角膜炎的诱发因素，包括潜在的内分泌病、既往角膜疾病、眼内手术和/或初诊时长期使用局部抗生素或皮质类固醇。诊断技术包括角膜细胞学检查，11只眼中有6只发现酵母或菌丝，真菌培养11只眼中有7只结果呈阳性。分离出的真菌包括枝孢属（n = 1）、金孢子菌属（n = 1）、弯孢属（n = 2）、曲霉属（n = 1）、青霉属（n = 1）和瓶霉属（n = 1）。11例患者中，6例仅通过药物治疗有效。2例在浅表角膜切除术后痊愈，3例因眼内炎或角膜疾病进展而被摘除眼球。本研究确定了发生真菌性角膜炎的潜在危险因素。
