Pieczarka Emily M, Russell Duncan S, Santangelo Kelly S, Aeffner Famke, Burkhard Mary Jo
Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA.
Vet Clin Pathol. 2014 Mar;43(1):89-93. doi: 10.1111/vcp.12117. Epub 2014 Jan 21.
An 11-year-old male castrated mixed-breed dog was presented for exercise intolerance, tetraparesis, and persistent hypoglycemia. Abdominal ultrasound examination revealed 2 nodules within the right limb of the pancreas. Cytology from one nodule was consistent with a carcinoma of neuroendocrine origin, with a primary differential diagnosis of insulinoma. Histologic evaluation and immunohistochemistry for synaptophysin and insulin confirmed the diagnosis of insulinoma. Additionally, there was a solitary nodule of mineralized compact bone composing approximately 60% of the mass. To the authors' knowledge, this is the first report of osseous metaplasia within an insulinoma (islet cell carcinoma).
一只11岁的去势混血雄性犬因运动不耐受、四肢轻瘫和持续性低血糖前来就诊。腹部超声检查发现胰腺右叶有2个结节。其中一个结节的细胞学检查结果与神经内分泌起源的癌一致，主要鉴别诊断为胰岛素瘤。对突触素和胰岛素进行组织学评估及免疫组化检查，确诊为胰岛素瘤。此外，还有一个由矿化致密骨构成的孤立结节，约占肿块的60%。据作者所知，这是胰岛素瘤（胰岛细胞癌）内骨化生的首例报告。
