Saito Motoaki, Tsounapi Panagiota, Oikawa Ryo, Shimizu Shogo, Honda Masashi, Sejima Takehiro, Kinoshita Yukako, Tomita Shuhei
Department of Pharmacology, Kochi University School of Medicine, Nankoku, 783-8505, Japan.
1] Division of Urology, Tottori University School of Medicine, 36-1 Nishi-cho, Yonago, 683-8503, Japan [2] Division of Molecular Pharmacology, Tottori University School of Medicine, 86 Nishi-cho, Yonago, 683-8503, Japan.
Sci Rep. 2014 Jan 22;4:3822. doi: 10.1038/srep03822.
In the light of increasing evidence that benign prostatic hyperplasia is associated with cardiovascular disease, we have investigated the relationship between prostatic blood flow and prostatic hyperplasia in the spontaneously-hypertensive-rat (SHR). Twelve-week-old male SHRs were treated with nicorandil for six weeks. Wistar-Kyoto rats were used as controls. Six weeks after nicorandil treatment, blood pressure and the prostatic blood flow were estimated, and tissue levels of malondialdehyde, HIF-1α, TGF-β1, bFGF, dihydrotestosterone, and α-SMA were measured. SHRs showed significant increases in blood pressure, tissue levels of malondialdehyde, HIF-1α, TGF-β1, bFGF, α-SMA and a significant decrease in the prostatic blood flow. Although treatment with nicorandil failed to alter the blood-pressure and α-SMA, it significantly ameliorated the increased levels of malondialdehyde, HIF-1α, TGF-β1, and bFGF. There were no significant differences in tissue levels of dihydrotestosterone among any groups. These data indicate that development of prostatic hyperplasia may be associated with prostatic hypoxia, which nicorandil prevents via its effect to increase the blood flow.
鉴于越来越多的证据表明良性前列腺增生与心血管疾病有关，我们研究了自发性高血压大鼠（SHR）前列腺血流与前列腺增生之间的关系。12周龄雄性SHR用尼可地尔治疗6周。以Wistar-Kyoto大鼠作为对照。尼可地尔治疗6周后，估计血压和前列腺血流，并测量丙二醛、HIF-1α、TGF-β1、bFGF、二氢睾酮和α-SMA的组织水平。SHR的血压、丙二醛、HIF-1α、TGF-β1、bFGF、α-SMA的组织水平显著升高，前列腺血流显著降低。虽然尼可地尔治疗未能改变血压和α-SMA，但它显著改善了丙二醛、HIF-1α、TGF-β1和bFGF升高的水平。各组间二氢睾酮的组织水平无显著差异。这些数据表明前列腺增生的发生可能与前列腺缺氧有关，尼可地尔通过增加血流的作用来预防这种情况。
