From the Department of Nephrology, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin 150001, China.
From the Department of Nephrology, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin 150001, China
QJM. 2014 Jun;107(6):443-9. doi: 10.1093/qjmed/hcu007. Epub 2014 Jan 20.
Patients with atherosclerotic cardio-cerebrovascular disease are at high risk of kidney dysfunction because of the overlap of several risk factors. The purpose of this study is to examine the prevalence and characteristics and risk factors for kidney dysfunction in the cardio-cerebrovascular disease population.
Renal functions of 1012 patients with the cardio-cerebrovascular disease were evaluated with the purpose of evaluating characteristics of the incidence, risk factors for kidney dysfunction in the cardio-cerebrovascular disease population.
In the univariate analysis, the major risk factors for kidney dysfunction in the patients with the cardio-cerebrovascular disease were age, gender, hypertension, diabetes mellitus, dyslipidemia and serum uric acid. In the patients with both hypertension and diabetes mellitus the percentages of significantly decreased eGFR were 25.6%. Results of multivariable analysis showed that diabetes mellitus (odds ratio (OR) 1.609, 95% confidence intervals (CI) 1.08-2.398, P = 0.019), hypertension (OR 1.547, 95% CI 1.049-2.281, P = 0.028) and serum uric acid (OR 1.009, 95% CI 1.007-1.010, P < 0.001) were independent risk factors for reduced kidney function.
In the context of the cardio-cerebrovascular disease kidney dysfunction is common and has a high prevalence. Patients with both cardio-cerebrovascular disease and kidney dysfunction at any stage should be recognized as high-risk population.
患有动脉粥样硬化性心脑血管疾病的患者由于存在多种危险因素，因此存在肾功能障碍的高风险。本研究旨在探讨心脑血管疾病人群中肾功能障碍的患病率、特征以及危险因素。
评估了 1012 例心脑血管疾病患者的肾功能，目的是评估心脑血管疾病患者中肾功能障碍的发生率、危险因素。
在单因素分析中，心脑血管疾病患者肾功能障碍的主要危险因素为年龄、性别、高血压、糖尿病、血脂异常和血尿酸。同时患有高血压和糖尿病的患者，eGFR 显著降低的比例为 25.6%。多变量分析结果显示，糖尿病（比值比 1.609，95%置信区间 1.08-2.398，P=0.019）、高血压（比值比 1.547，95%置信区间 1.049-2.281，P=0.028）和血尿酸（比值比 1.009，95%置信区间 1.007-1.010，P<0.001）是肾功能下降的独立危险因素。
在心脑血管疾病患者中，肾功能障碍很常见且患病率较高。任何阶段同时患有心脑血管疾病和肾功能障碍的患者应被视为高危人群。
