Li Zhi-Jun, Yi Chen-Ju, Li Jing, Tang Na
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Oncotarget. 2017 Apr 11;8(15):24110-24118. doi: 10.18632/oncotarget.15902.
The role of uric acid as a risk factor for cardio-cerebrovascular diseases is controversial. In this study, we aimed to investigate the relationship between serum uric acid level and the risk of cardio-cerebrovascular events in middle-aged and non-obese Chinese men.
We included 3152 participants from the health examination center of Tongji Hospital from June 2007 to June 2010. Clinical examination and medical records were collected at the annual health examination. The hazard ratios (HRs) of uric acid for cardio-cerebrovascular events were calculated by Cox proportional hazards models. Generalized additive model and threshold effect analysis were used to explore the non-linear relationship between serum uric acid level and the incidence of cardio-cerebrovascular event.
The mean follow-up time was 52 months. When the participants were classified into four groups by the serum acid quarter (Q1-Q4), the HRs (95% CI) of Q2-Q4 for cardio-cerebrovascular events were 1.26 (0.83, 1.92), 1.97 (1.33, 2.91) and 2.05 (1.40, 3.01), respectively, compared with the reference (Q1). The actual incidence and conditional incidence of cardio-cerebrovascular events in the high serum acid group were higher than those in the low serum acid group, which were stratified by the turning point (sUA = 372 μmol/L). We also showed a strong prognostic accuracy of the multiple variable-based score in 3 years and 5 years, with area under the receiver operating characteristic (ROC) curve of 0.790 (0.756-0.823) and 0.777 (0.749-0.804), respectively.
Serum uric acid level is a strong risk factor for cardio-cerebrovascular events.
尿酸作为心脑血管疾病危险因素的作用存在争议。在本研究中，我们旨在探讨血清尿酸水平与中国中年非肥胖男性心脑血管事件风险之间的关系。
我们纳入了2007年6月至2010年6月期间来自同济医院健康体检中心的3152名参与者。在年度健康体检时收集临床检查和医疗记录。通过Cox比例风险模型计算尿酸发生心脑血管事件的风险比（HRs）。采用广义相加模型和阈值效应分析来探讨血清尿酸水平与心脑血管事件发生率之间的非线性关系。
平均随访时间为52个月。当根据血清尿酸四分位数（Q1-Q4）将参与者分为四组时，与参照组（Q1）相比，Q2-Q4发生心脑血管事件的HRs（95%CI）分别为1.26（0.83，1.92）、1.97（1.33，2.91）和2.05（1.40，3.01）。根据转折点（血清尿酸 = 372μmol/L）分层，高血清尿酸组心脑血管事件的实际发生率和条件发生率均高于低血清尿酸组。我们还显示基于多变量的评分在3年和5年时具有较强的预后准确性，受试者操作特征（ROC）曲线下面积分别为0.790（0.756-0.823）和0.777（0.749-0.804）。
血清尿酸水平是心脑血管事件的一个重要危险因素。
