Williams S J, Baird-Lambert J A, Farrell G C
Department of Medicine, University of Sydney, NSW, Australia.
Lancet. 1987 Oct 24;2(8565):939-41. doi: 10.1016/s0140-6736(87)91422-x.
1 day after a single intramuscular injection of recombinant human interferon alpha A in 5 patients with stable chronic active hepatitis B and 4 healthy controls theophylline clearance was significantly reduced and theophylline elimination half-life was significantly increased. There was a clear relation between pre-treatment and post-treatment theophylline clearance rates, indicating that the greatest effect of interferon was in subjects who were fast metabolisers of theophylline. These observations support the contention that the actions of endogenous interferon may account for the effects of immunisations and viral infections on hepatic drug metabolism. Moreover, treatment with interferon may cause clinically important drug interactions.
在5例慢性活动性乙型肝炎稳定期患者和4名健康对照者单次肌内注射重组人干扰素αA后1天，茶碱清除率显著降低，茶碱消除半衰期显著延长。治疗前和治疗后的茶碱清除率之间存在明显关联，表明干扰素对茶碱代谢快的受试者影响最大。这些观察结果支持了内源性干扰素的作用可能是免疫接种和病毒感染对肝脏药物代谢产生影响的原因这一论点。此外，干扰素治疗可能会导致具有临床重要性的药物相互作用。
