干扰素对安替比林代谢的抑制作用。
Inhibition of antipyrine metabolism by interferon.
作者信息
Williams S J, Farrell G C
出版信息
Br J Clin Pharmacol. 1986 Nov;22(5):610-2. doi: 10.1111/j.1365-2125.1986.tb02943.x.
Abstract
Antipyrine clearance was measured before and 1 day after administration of a single intramuscular dose of recombinant human leukocyte alpha A interferon. In the nine patients studied, antipyrine clearance was reduced after interferon from 0.49 (0.21-1.13) ml kg-1 min-1 (median (range)) to 0.41 (0.20-1.07) ml kg-1 min-1, P less than 0.01. In individual patients, the decrement in antipyrine clearance was variable, ranging from 5-47% (median, 16%). This study provides the first direct evidence that interferon inhibits hepatic oxidative drug metabolism in humans and alerts clinicians to the possibility of potentially toxic drug-drug interactions.
摘要
在单次肌肉注射重组人白细胞αA干扰素之前及之后1天，测定安替比林清除率。在研究的9名患者中，干扰素注射后安替比林清除率从0.49（0.21 - 1.13）毫升·千克⁻¹·分钟⁻¹（中位数（范围））降至0.41（0.20 - 1.07）毫升·千克⁻¹·分钟⁻¹，P<0.01。在个体患者中，安替比林清除率的下降幅度各不相同，范围为5% - 47%（中位数为16%）。本研究提供了首个直接证据，表明干扰素会抑制人体肝脏的氧化药物代谢，并提醒临床医生注意潜在的毒性药物相互作用的可能性。
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