Singer James R, Pearce Zachary D, Westhouse Scott J, Siebert Karl J
*Department of Ophthalmology Michigan State University, East Lansing †Metro Health Hospital, Wyoming, MI.
J Glaucoma. 2015 Jan;24(1):84-6. doi: 10.1097/IJG.0000000000000037.
To report a novel case of acute bilateral uveal effusions, angle closure, and acute myopia induced by administration of chlorthalidone.
Case report.
Bilateral shallow anterior chambers, high intraocular pressure, and a myopic shift were encountered in a patient 1 week after initiation of chlorthalidone. Ultrasound evaluation revealed bilateral ciliochoroidal effusions, appositional angle closure, and suspected ciliary body edema. Cessation of chlorthalidone, in addition to administration of cycloplegics and ocular antihypertensives, resulted in prompt resolution of this idiosyncratic reaction.
The antihypertensive medication chlorthalidone may cause bilateral uveal effusions inducing acute angle-closure glaucoma and acute myopia.
报告一例因服用氯噻酮引起急性双侧葡萄膜渗漏、房角关闭和急性近视的罕见病例。
病例报告。
一名患者在开始服用氯噻酮1周后出现双侧前房变浅、高眼压和近视性屈光不正。超声检查显示双侧睫状体脉络膜渗漏、房角关闭及疑似睫状体水肿。停用氯噻酮并给予睫状肌麻痹剂和眼部降压药后，这一特异反应迅速消退。
抗高血压药物氯噻酮可能导致双侧葡萄膜渗漏，进而引起急性闭角型青光眼和急性近视。
