乳房缩小术后坏疽性脓皮病：外用他克莫司和类固醇治疗
Pyoderma gangrenosum following breast reduction: treatment with topical tacrolimus and steroids.
作者信息
Doren Erin Louise, Aya-ay Melanie Lynn
机构信息
Dr Doren is an Integrated Plastic Surgery Resident in the Department of Surgery, Division of Plastic Surgery, University of South Florida, Tampa, Florida.
出版信息
Aesthet Surg J. 2014 Mar;34(3):394-9. doi: 10.1177/1090820X13520448. Epub 2014 Jan 21.
UNLABELLED
Pyoderma gangrenosum (PG) is a rare, noninfectious, inflammatory dermatosis usually associated with autoimmune disorders. Wounds may mimic a necrotizing infection, and the diagnosis is usually made after antibiotic therapy fails. Debridement may cause even larger wounds because of pathergy, so PG treatment consists of corticosteroids and local wound care. Pyoderma gangrenosum can be a devastating complication of breast and aesthetic surgery. We describe a case of PG following unilateral breast reduction that resulted in systemic inflammatory response; after treatment with prednisone and topical tacrolimus, the PG was resolved. The application of topical tacrolimus may reduce the need for prolonged corticosteroids.
LEVEL OF EVIDENCE
未标记
坏疽性脓皮病（PG）是一种罕见的、非感染性炎症性皮肤病，通常与自身免疫性疾病相关。伤口可能类似坏死性感染，通常在抗生素治疗失败后做出诊断。由于同形反应，清创可能导致更大的伤口，因此PG的治疗包括使用皮质类固醇和局部伤口护理。坏疽性脓皮病可能是乳房和美容手术的严重并发症。我们描述了一例单侧乳房缩小术后发生PG并导致全身炎症反应的病例；经泼尼松和外用他克莫司治疗后PG得到缓解。外用他克莫司的应用可能会减少长期使用皮质类固醇的需求。
证据级别
5级。
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